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Here, we present very fast dating algorithms, based on a Gaussian S.J.. Rambaut. A. Real-time characterization of the molecular.

Phylogenies provide a useful way to understand the evolutionary history of genetic samples, and data sets with more than a thousand taxa are becoming increasingly common, notably with viruses e. Dating ancestral events is one of the first, essential goals with such data. However, current sophisticated probabilistic approaches struggle to handle data sets of this size. Here, we present very fast dating algorithms, based on a Gaussian model closely related to the Langley—Fitch molecular-clock model.

We show that this model is robust to uncorrelated violations of the molecular clock. Our algorithms apply to serial data, where the tips of the tree have been sampled through times. They estimate the substitution rate and the dates of all ancestral nodes. When the input tree is unrooted, they can provide an estimate for the root position, thus representing a new, practical alternative to the standard rooting methods e.

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Make social connections and possibly find love at this awesomely exciting singles social event! You’ll enjoy an evening of meeting new people! Our friendly host will be orchestrating the event and making introductions among the group. You’ll then be rotating from table to table in small groups and meeting all those of the opposite sex in attendance. As you rotate and meet people, the host will be announcing fun little mini games to help spice up the interaction.

We find this makes the speed dating a lot more fun than standard speed dating and takes a lot of the pressure off of you having to come up with new things to talk about with each person. We give you time to ask questions and get to know everyone, but the games make an excellent ice breaker.

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The program will feature approximately minute conversations between one bookstore and one publicist at a time. Preregistration and prepayment are required. Space is limited, and registration is first-come, first-served. Booksellers will receive their table assignments via e-mail prior to BEA. ABC Group members and friends of CBC who purchase tickets are invited to sit down and share an intimate and relaxing teatime with a beloved author or illustrator.

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Charles St. Hfq is a ubiquitous, Sm-like RNA binding protein found in most bacteria and some archaea. Because sRNAs regulate many stress response pathways in bacteria, Hfq is essential for adaptation to different environments and growth conditions. The chaperone activities of Hfq arise from multi-pronged RNA binding by three different surfaces of the Hfq hexamer. The interplay between structured and disordered domains of Hfq optimizes sRNA-mediated post-transcriptional regulation, and is a common theme in RNA chaperones.

Hfq can also directly bind certain mRNAs and regulate their translation 14 — Hfq accomplishes these varied functions by using different surfaces to simultaneously recognize the sequence motifs and structural features of its target RNAs. Hfq is best known for its function in post-transcriptional gene regulation by sRNA. Many sRNAs act by base pairing with a complementary sequence in the target mRNA, either sequestering the ribosome binding site RBS 19 or rendering it more accessible for translation 20 , Negative regulation occurs when the sRNA anneals to or around the RBS in a manner that inhibits binding of the ribosome These overlapping regulatory interactions may synergistically act towards a similar physiological outcome, or could antagonize each other.

Consequently, bacterial non-coding RNAs and Hfq variants may have co-evolved in bacterial lineages 30 , so that specific regulatory pathways are prioritized over others. For example the appearance of a long Hfq C-terminal domain is coincident with the expansion of the sRNA repertoire in Enterobacteriaceae 30 , and the establishment of two classes of sRNAs that compete for Hfq with different efficiencies 31 , One challenge in understanding Hfq-mediated regulation is that the RNA substrates vary in size, structure, and sequence motif combinations.

Hfq chaperone brings speed dating to bacterial sRNA

Choosing the right mentor is crucial for effective mentorship. Yet, many medical students have difficulties finding a suitable mentor. Thus we developed mentoring speed dating MSD as a promising matching tool to connect students and faculty mentors successfully. They conducted four focus groups with mentees and mentors who participated in a mentoring speed dating event and analyzed transcripts using conventional content analysis with inductive categorizing.

Thus we developed mentoring speed dating (MSD) as a promising matching tool to with mentees and mentors who participated in a mentoring speed dating event and Frambach JM, van der Vleuten CP, Durning SJ.

Saturday, February 8, When: Saturday Feb. Why: To Meet with a bunch of other singles to see who you connect with and want to see again! What can I expect if I attend an event? You will get to meet individually with every person there of the opposite gender and during your 5 minutes with them you start off by asking at least one of the 20 questions we give you!

After time is up, you will then secretly circle yes or no on your card if you are interested in seeing that person again. Then you can get right back in touch with them to continue getting to know each other!

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